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Manreet (Sonia) Padwal

Manreet (Sonia) Padwal, PhD

Start-date: October 2017

Current position

Research Associate (Since October 2017)

 

Past Positions

 

2012-2017: PhD Student in the Medical Sciences

2015-2017: Clinical Study Coordinator

 

Projects:

 

My doctoral research focused on investigating the complications of long-term peritoneal dialysis for patients with chronic kidney disease. I have elucidated the role of matrix metalloproteinases (MMP) and WNT signaling in the development of peritoneal angiogenesis and identified potential biomarkers associated with poor clinical outcomes. I have also been involved in clinical research investigating the genetic component behind progressive peritoneal fibrosis. On a large scale, my research aims to understand the cellular pathways involved in the pathogenesis of peritoneal membrane injury to improve current therapies for patients. Currently, I am investigating the mechanisms behind idiopathic pulmonary fibrosis as a research associate at the Firestone Institute for Respiratory Health and the McMaster Immunology Research Center.

 

Email Sonia at padwalmsk@gmail.com

 

Peer reviewed manuscripts:

 

  1. Padwal M, Cheng G, Liu L, Boivin F, Gangji A, Brimble S, Bridgewater D, and Margetts PJ. WNT Signaling is Required for Peritoneal Membrane Angiogenesis. Am J Physiol Renal Physiol. (2017). Submitted.
  2. Padwal M, Siddique, I, Wu, L, Tang K, Boivin, F, Liu, L, Robertson, J, Bridgewater, D, West-Mays, J, Gangji, A, Brimble, S, Margetts PJ. Matrix metalloproteinase 9 is associated with peritoneal membrane solute transport and induces angiogenesis through b-catenin signaling. Nephrol Dial Transplant 32(1), 50-61 (2017).
  3. Padwal M, Margetts PJ. Experimental systems to study the origin of the myofibroblast in peritoneal fibrosis. Kidney Res and Clin Pract 35(3), 133-141 (2016).

 

Abstracts:

 

  1. Padwal M, Liu L, Margetts PJ. The Role of WNT Signaling in Peritoneal Membrane Injury. Journal American Society Nephrology, 27;2016. American Society Nephrology Conference. Chicago, IL, USA. November 2016.
  2. Padwal M, Margetts PJ. Non-canonical WNT signaling inhibits peritoneal fibrosis. Peritoneal Dialysis International. 35;2016 International Society of Peritoneal Dialysis. Melbourne, Australia, February 2016.
  3. Padwal M, Liu L, Gangji A, Brimble KS, Margetts PJ. (2016) Epigenetic modification of peritoneal mesothelial cells. Peritoneal Dialysis International. 35;2016. International Society of Peritoneal Dialysis Conference. February 2016, Melbourne Australia.
  4. Margetts P, Padwal M, Liu L, Cheng, G. The Wnt Signalling Pathway is active during Peritoneal Fibrosis. Journal American Society Nephrology. 25; 2014. American Society of Nephrology Conference. Philadelphia, PA, USA.  2014.
  5. Padwal M, Siddique I, Tang K, Liu, L, Margetts PJ. (2014). The Role of Matrix Matrix Metalloproteinase 9 (MMP9) mRNA is Associated with Peritoneal Membrane Transport. Peritoneal Dialysis International. 34; 2014. International Society of Peritoneal Dialysis Conference. Madrid, Spain. September 2014.
  6. Cheng G, Padwal M, Liu L, Gangji A, Brimble KS, Margetts PJ. The Wnt Signaling Pathway is activated during Peritoneal Fibrosis. Peritoneal Dialysis International. 34; 2014. International Society of Peritoneal Dialysis Conference. Madrid, Spain. September 2014.
  7. Padwal M, Liu L, Siddique I, Ghayur A, West-mays A, Gangji A, Brimble S, Margetts PJ, Matrix Metalloproteinases in Peritoneal Fibrosis. Canadian Society of Nephrology Conference. April, 2013. Montreal, QC, CA.