McMaster University

Ask Lab

Kjetil Ask

Kjetil Ask, PhD

Current standing

Associate Professor, Firestone Institute for Respiratory Health, Department of Medicine, Division: Respirology

Associate memberships

  • McMaster Immunology Research Centre
  • Department of Biochemistry and Biomedical Sciences
  • Hamilton Scleroderma Group

Education

  • PhD, University of Burgundy (Dijon, France), 2003
  • Post-doctoral fellowship: McMaster University (Hamilton, Canada), 2004-2008
  • Post-doctoral fellowship: NHLBI, NIH, (Bethesda, USA), 2008-2010

Academic Interests

  • Director: McMaster Demystifying Medicine Seminar Series
  • Member of McMaster University Animal Research Ethics Board
  • Executive committee member and Area Coordinator in the Medical Sciences Graduate Program
  • Facilitator 4DM3: Demystifying Medicine undergraduate course in Medical and Biomedical Knowledge Translation

Selected publications

  • Ayaub EA, Dubey A, Imani J, Botelho F, Kolb MRJ, Richards CD, Ask K. Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis. Sci. Rep. 2017, Oct 16/7:41598, PMID 2903860

  • Yum V, Carlisle R, Lu C, Brimble E, Chahal J, Upagupta C, Ask K, Dickhout JG. Endoplasmic reticulum stress inhibition limits the progression of chronic kidney disease in the Dahl-sensitive rat. Am J Physiol Renal Physiol. 2017 Jan 1;312(1):F230-F244. PMID 28069662

  • Mohammed-ali Z, Lu C, Marway M, Carlisle R, Ask K, Lukic D, Krepinsky JC, Dickhout JG. Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria. Sci Rep 2017, Feb 2(7):41572, PMID 2814896

  • Mukherjee S, Ayaub E, Murphy J, Lu C, Kolb M, Ask K, Janssen L. Nifedipine Disrupts Signaling in Fibroblasts and Attenuates Bleomycin-Induced Fibrosis. Am J Respir Cell Mol Biol, 2015 Feb 9; Epub ahead of print. PMID: 25664495

  • Kolb PS, Ayaub EA, Zhou W, Yum V, Dickhout JG, Ask K. The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis. Int J Biochem Cell Biol, 2015 Feb 7; Epub ahead of print. PMID:25660369

  • Ayaub EA, Kolb PS, Mohammed-ali Z, Tat V, Murphy J, Bellaye PS, Shimbori C, Boivin FJ, Lai R, Lynn EG, Lhotak S, Bridgewater D, Kolb MRJ, Inman MD, Dickhout JG, Austin RC and Ask K. GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis. Journal of Pathology. http://www.ncbi.nlm.nih.gov/pubmed/27135434

  • Carlisle RE, Brimble E, Werner KE, Cruz GL, Ask K, Ingram AJ, Dickhout JG. 4-Phenylbuturate inhibits tunicamycin-induced acute kidney injury via CHOP/GADD153 repression. PLOS one, 2014 Jan 8;9(1):e84663  PMID:24416259

  • Holme JA, Nyvold HE, Tat V, Arlt V, Bhargava A, Gutzkow KB, Solhaug A, Låg M, Becher R, Schwarze PE, Ask K, Ekeren L, and Øvrevik J. Mechanisms linked to differences in the mutagenic potential of 1,3-dinitropyrene and 1,8-dinitropyrene. Toxicology Reports (1) 459-473, 2014

  • Hirota JA, Hiebert PR, Gold M, Wu D, Graydon C, Smith JA, Ask K, McNagny K, Granville DJ, Knight DA: Granzyme B deficiency exacerbates lung inflammation in mice following acute lung injury. Am J Resp Cell Mol Biol 2013 May 3, PMID:23642129

  • Wei J, Rahman S, Ayaub E, Dickhout JG, Ask K. Protein Misfolding and Endoplasmic Reticulum Stress in Chronic Lung Disease. Chest, 2013 Apr 1; 143(4):1098-105. PMID: 23546482

  • Ask K, Eickelberg O, Gauldie J, Kaminski N, Kolb M. Have advanced research technologies made real impact on respiratory medicine? Respirology. 15(6):876-80. 2010. PMID:20646243

  • Moeller A, Gilpin S, Ask K, Cox G, Cook DJ, Gauldie J, Margetts PJ, Farkas L, Dobranowski J, Boylan C, O’Byrne PM, Strieter R and Kolb MRJ. Circulating Fibrocytes Are an Indicator for Poor Prognosis in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 179:588-94, 2009. PMID:19151190

  • Ask K, Moeller A, Farncombe T, Labiris R, Kolb M. The use of small animal imaging in respiratory drug discovery. Drug Discovery Today. Therapeutic Strategies; 5-2, 2008. [external link]

  • Ask K, Labiris RN, Farkas L, Moeller A, Froese AR, Farnecombe T, McClelland G, Inman MD, Gauldie J and Kolb M. Comparison between conventional and clinical assessment of experimental lung fibrosis. J Transl Med. Apr 10; 6:16, 2008: PMID:18402687

  • Ask K, Bonniaud P, Nejman B, Maass K, Eickelberg O, Margetts PJ, Waburton D, Groffen J, Gauldie J and Kolb M. Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta 3. Int J Biochem Cell Biol; 40:484-495, 2008. PMID:17931953

  • Moeller A, Ask K, Gauldie J and Kolb M. The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? Int J Biochem Cell Biol. 40:362-382, 2008. PMID:17936056

  • Ask K, Martin GEM, Bonniaud P, Kolb M and Gauldie J. Strategies Targeting Fibrosis in Pulmonary Disease. Drug Discovery Today: Therapeutic Strategies. 3(3): 389-394, 2006.[External link]

  • Ask K, Martin GEM, Kolb M and Gauldie J. Targeting Genes for Treatment in Idiopathic Pulmonary Fibrosis: Challenges and Opportunities, Promises and Pitfalls. Proc Am Thorac Soc. 3:389-93, 2006. PMID:16738206